The Occupational Safety Leadership Podcast
Measuring Worker Fatigue with James Walsh of Hyperion Biotechnology - part 2

- Broadcast on
- 27 Jun 2026
Fatigue contributes to accidents, now there's an accurate test. This is part 2 of fatigue testing using non-invasive saliva chews with James Walsh. Hyperion Biotechnology developed a non‑invasive saliva‑based test that measures biological markers linked to fatigue, stress, and readiness for duty. The goal is to give employers an objective way to identify when workers may be too fatigued to perform safely — especially in high‑risk environments.
Guest information - James Walsh https://www.linkedin.com/in/james-walsh-675193129/
Hyperion Biotechnology - https://hyperionbiotechnology.com/
🔬 1. What the Test MeasuresWhat is measured is a proprietary, patented biomarker for fatigue. It’s not cortisol. The peptide ratio I describe is the Fatigue Biomarker Index is a biomarker assay that is exclusive to Hyperion (that we developed with the Army and Air Force).
🧪 2. How the Test Works-
Employees provide a simple saliva sample (no needles, no medical staff required).
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The sample is analyzed using Hyperion’s proprietary assay.
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Results indicate whether the worker is:
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Borderline fatigued
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Significantly fatigued
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This creates an objective fatigue score, rather than relying solely on self‑reporting or supervisor observation.
🛡️ 3. Why It Matters for Occupational SafetyFatigue is a major contributor to:
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Reduced reaction time
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Poor decision‑making
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Increased error rates
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Higher injury risk
Hyperion’s test gives safety leaders a data‑driven tool to identify fatigue before it leads to incidents — especially in:
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Transportation
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Manufacturing
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Military operations
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Shift work
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High‑hazard environments
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Saliva testing provides objective fatigue data.
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Non‑invasive collection makes it practical for daily or periodic use.
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Results help guide fit‑for‑duty decisions.
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Supports a proactive approach to fatigue risk management.